Transgenic animals to produce therapeutic proteins

technological platforms

Bio Sidus focuses on the R&D of novel technologies for the cost-effective high-yield production of recombinant proteins for pharmaceutical applications.

Production of Human Growth Hormone (somatropin) in the milk of cows through the establishment of a herd of cloned transgenic cows has been the first achieved target in the overall Bio Sidus's "Pharmaceutical Dairy" project, positioning Argentina in a select group of countries with skills in cloned transgenic cattle, and as the first country to have cows as bioreactors to produce somatropin.

The development of the final pharmaceutical form of hGH from the milk of cloned transgenic cows has been concluded. Bioequivalence results against a reference product have been satisfactory and a comparative efficacy clinical protocol on children with growth retardation will be initiated.

Other target proteins under development include the bovine growth hormone, human insulin and monoclonal antibodies.